Extended Data Fig. 4: WGBS and RRBS datasets cross-validation.
From: Epigenetic divergence during early stages of speciation in an African crater lake cichlid fish
a. Heatmap showing Spearman’s correlation scores (Euclidean distances and complete-linkage clustering) of methylome variation at WGBS-DMRs covered by all RRBS samples (DMR count, n = 413) and showing strong population-specific methylome patterns (see Methods and Supplementary Notes). b. Heatmap showing average methylation levels averaged across all RRBS and WGBS samples (average mCG/CG per group) at WGBS-DMRs for each of the three WGBS-DMRs pairwise comparison (Fig.1g). Number of DMRs shown next to each heatmap. c. Total number of DMRs identified using the RRBS samples. The proportion of RRBS-DMRs overlapping with WGBS-DMRs is shown in pink. d. Table summarising the total number of DMRs found using both RRBS and WGBS datasets. Biological replicates: WGBS: Benthic (B), n = 3; Littoral (L) and Riverine (R), n = 2; RRBS, Benthic and Littoral, n = 12; River, n = 11.
