Extended Data Fig. 4: hesC appears to have lost its ancestral role of repressing larval skeletal cell specification in H. erythrogramma. | Nature Ecology & Evolution

Extended Data Fig. 4: hesC appears to have lost its ancestral role of repressing larval skeletal cell specification in H. erythrogramma.

From: Recent reconfiguration of an ancient developmental gene regulatory network in Heliocidaris sea urchins

Extended Data Fig. 4: hesC appears to have lost its ancestral role of repressing larval skeletal cell specification in H. erythrogramma.The alternative text for this image may have been generated using AI.

Derived expression patterns of hesC in H. erythrogramma at a, cleavage; b, blastula; and c, d, larva stage embryos. Micrographs derive from a single round of in-situ experiments. e, f, Control and MASO knock-down of HesC in H. erythrogramma (early larva; scale bar 100 µm). Polarized light illuminates skeletal elements. HesC knockdown appears to show no phenotype, a dramatic change from the ancestral dGRN. Injection experiments were replicated twice.

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