Extended Data Fig. 6: Histogram of ROH after combining simulated close-kin offspring, and expected densities for certain parental relationships.

For the three parental relatedness scenarios (half-siblings, first cousins and second cousins), 1000 offspring were simulated with the software pedsim (Methods). For comparison with Fig. 6b, the histogram of every panel was created after combining ten simulated individuals at different proportions. Histograms with all simulated first cousins, or 80% first cousins and 20% second cousins mostly closely match the histogram from the combined Hagios Charalambos individuals.