Extended Data Fig. 1: The correlation between mutation count and collection date.
From: Immune evasion and ACE2 binding affinity contribute to SARS-CoV-2 evolution
a) The correlation between nonsynonymous mutation count and collection date. Two hundred sequences were randomly selected from each month based on the collection date. The segmented regression line was fitted using automatic piecewise linear regression, and the mutation rate was estimated as the slope of the regression line. We conducted 100 samplings and added the resulting median and standard deviation of the estimated mutation rate on top of the regression line. T1 represents Dec 24, 2019, which is the collection date of the first open-access SARS-CoV-2 sequence. b) The correlation between nonsynonymous mutation count and collection date for major lineages. c) The correlation between synonymous mutation count and collection date. D) The correlation between synonymous mutation count and collection date for major lineages.
