Extended Data Fig. 6: Evolution of lung-related regulatory elements. | Nature Ecology & Evolution

Extended Data Fig. 6: Evolution of lung-related regulatory elements.

From: Origin and stepwise evolution of vertebrate lungs

Extended Data Fig. 6

a-b, Heatmaps showing the distribution of CUT&Tag signals for histone modifications H3K27ac and H3K4me1 around gene transcription start sites (TSS) in embryonic chicken lungs at 9, 11, and 19 days, and at postnatal day 23(a), as well as in 4-week-old mouse lungs (b). c, Stacked plot depicting the relative genomic positions of selected genes and their nearby CNEs in humans, with different rows representing the evolutionary origins of the CNEs. d, Detailed view of 10 CNEs near the TBX4 gene. Top: human lung Hi-C interactions, TAD (Topologically Associating Domain) distribution, and CNE positions (using hg38 as reference). Middle: H3K27ac signals in chicken and mouse embryonic lungs. Bottom: Sequence conservation across multiple species.

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