Extended Data Fig. 2: Cross-species integration of lung cells from nine vertebrate species. | Nature Ecology & Evolution

Extended Data Fig. 2: Cross-species integration of lung cells from nine vertebrate species.

From: Origin and stepwise evolution of vertebrate lungs

Extended Data Fig. 2

a, UMAP plots showcasing lung cell distributions from each species, derived from merged SAMAP coordinates. Species range from Senegal bichir to rat, illustrating evolutionary diversity. b, Stacked bar chart quantifying the proportional composition of cell types across species. This visualization highlights interspecies variations in lung cellular makeup. c, Comparative UMAP plots demonstrating the integration efficacy of six different computational methods (CCA, RPCA, MNN, scANVI, scVI, and LIGER) on lung cells from all nine species. The upper row is color-coded by species origin, while the lower row is color-coded by cell types as annotated from each species.

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