Extended Data Fig. 1: Resistance trajectories plotted against the number of rounds for each lineage.
From: Cryptic phenotypic variation emerges rapidly during the adaptive evolution of a carbapenemase
Colors indicate grouping based on positions associated with CAZ resistance: blue (D179Y), green (H274Y), yellow (L169P), and red (S171P). Panels show MIC values for CAZ, cefotaxime (CTX), cefoxitin (FOX), and imipenem (IMI), as labeled in the upper-right corner. Note that divergence in resistance profiles peaks around rounds 1–2, similarly to other traits (Fig. 3), underscoring how rapidly populations diverge after fixation of the first mutation.
