Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Population genetics

Deep mutational scans clarify the record of evolution

Nature Ecology & Evolution volume 9, pages 2189–2190 (2025)Cite this article

Subjects

Population genetics simulations and experimental evolution in yeast reconcile the apparent contradiction between high levels of beneficial mutations observed in the laboratory and long-term evolutionary patterns that mimic neutrality.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Antagonistic pleiotropy and environmental fluctuations shape fixation and polymorphism patterns.

References

  1. Barrick, J. E. & Lenski, R. E. Nat. Rev. Genet. 14, 827–839 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Teotónio, H., Estes, S., Phillips, P. C. & Baer, C. F. Genetics 206, 691–716 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Song, S., Chen, P., Shen, X. & Zhang, J. Nat. Ecol. Evol. https://doi.org/10.1038/s41559-025-02887-1 (2025).

    Article  PubMed  Google Scholar 

  4. Fowler, D. M. & Fields, S. Nat. Methods 11, 801–807 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Hietpas, R. T., Jensen, J. D. & Bolon, D. N. A. Proc. Natl Acad. Sci. USA 108, 7896–7901 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Figliuzzi, M., Jacquier, H., Schug, A., Tenaillon, O. & Weigt, M. Mol. Biol. Evol. 33, 268–280 (2016).

    Article  CAS  PubMed  Google Scholar 

  7. Livesey, B. J. & Marsh, J. A. Genome Biol. 26, 104 (2025).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Barreto, H. C. & Gordo, I. Nat. Rev. Microbiol. 21, 590–603 (2023).

    Article  CAS  PubMed  Google Scholar 

  9. Zhao, S. et al. Cell Host Microbe 25, 656–667.e8 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Rutter, M. T., Shaw, F. H. & Fenster, C. B. Evolution 64, 1825–1835 (2010).

    Article  PubMed  Google Scholar 

  11. Chen, P. & Zhang, J. Nat. Ecol. Evol. 4, 461–469 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  12. Gillespie, J. H. Genet. Res. 21, 115–120 (1973).

    Article  Google Scholar 

  13. Cvijović, I., Good, B. H., Jerison, E. R. & Desai, M. M. Proc. Natl Acad. Sci. USA 112, E5021–E5028 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  14. Vigué, L. & Tenaillon, O. Proc. Natl Acad. Sci. USA 120, e2304177120 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  15. Couce, A. et al. Science 383, eadd1417 (2024).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Université Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France

    Manolo Mischler & Olivier Tenaillon

Authors
  1. Manolo Mischler
    View author publications

    Search author on:PubMed Google Scholar

  2. Olivier Tenaillon
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Olivier Tenaillon.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mischler, M., Tenaillon, O. Deep mutational scans clarify the record of evolution. Nat Ecol Evol 9, 2189–2190 (2025). https://doi.org/10.1038/s41559-025-02902-5

Download citation

  • Published:

  • Version of record:

  • Issue date:

  • DOI: https://doi.org/10.1038/s41559-025-02902-5

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing