Abstract
Here we explore the well-being of sexual and gender diverse (LGBTQ+) people using three socioecological dimensions of homophobia, family, community and national and their socioeconomic status via a convenience sample of 82,324 participants. Participants from the Middle East and North Africa reported the lowest subjective well-being (mean 4.78, s.d. of 2.70), followed by Eastern Europe and Central Asia (mean 5.22, s.d. of 2.13). The Structural Homophobic Climate Index (β = −1.68, 95% confidence interval (CI) −2.38 to −0.99) and family-level homophobia (β = −0.84, 95% CI −0.87 to −0.81) were negatively related to LGBTQ+ well-being. Economic precarity significantly interacted with the negative association between homophobia and participants’ well-being. The weight of a country’s homophobic climate on well-being was nearly halved for economically secure participants compared with those economically deprived. Participants unaware of their human immunodeficiency virus status reported the lowest well-being (β = −0.20, 95% CI −0.23 to −0.16) controlling for homophobia. Public health measures should address homophobic stigma and discrimination, focusing on the lowest socioeconomic strata.
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Data availability
The data supporting the findings of this study are available from the corresponding author (E.L.) to all accredited researchers upon request and signature of a declaration of confidentiality and privacy. Please note that due to the existence of national legislation criminalizing sexual and gender diverse people, the above declaration requests all data related to the LGBTI Global Survey to be treated following the EU Directive 95/46/EC and as amended, replaced or superseded from time to time, including by the EU General Data Protection Regulation 2016/679 (GDPR).
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Acknowledgements
We thank the 115,000 LGBTQ+ individuals who responded to the LGBTQ+ Happiness Survey. We thank all the LGBTQ+ networks, civil society organizations, community-based organizations, UNAIDS regional and country offices and partners who promoted the survey. We also thank community activists and celebrities, as well as social networks and ‘dating’ applications, for promoting the survey. We are grateful for the support and expertise of L. Bouvard, A. Lacombe, M. Mahy, C. Protopospescu, K. Sabin, M. Ufarte and A. Yakusik. E.L. received funding from UNAIDS, Geneva, Switzerland. B.V. received funding from the French government under the France 2030 investment plan managed by the French National Research Agency (reference no. ANR-17-EURE-0020) and the Excellence Initiative of Aix-Marseille University - A*MIDEX. V.L. received funding from the Agence nationale de recherche sur le sida et les hépatites virales: grant 22203 PhD fellowship. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.
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E.L., S.H. and B.V. conceptualized the Global LGBTQ+ Happiness Survey. E.L. and S.H. conducted and implemented the Global LGBTQ+ Happiness Survey. E.L., B.V. and S.H. are exclusively responsible for the survey data used in this study. E.L., B.V., V.L. and S.B. conceptualized the study. E.L., B.V., V.L., S.H. and S.B. drafted the paper. V.L., B.V. and E.L. conducted the data analysis. E.L., B.V., V.L. and S.H. were primarily responsible for the final content of the paper. All authors had full access to all the data in the study. E.L., B.V. and V.L. verified the underlying data of the study. All authors approved the final paper. All authors contributed to this article in their personal capacity. The views expressed are their own and do not necessarily represent the views of their respective institutions.
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E.L. and S.H. declare they work for UNAIDS and the LGBTQ+ Foundation, respectively. Both organizations are engaged in advocacy on HIV and the reduction of societal barriers, including those applied to sexual and gender diverse communities. The other authors declare no competing interests.
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Nature Human Behaviour thanks Samuel Mann, Sean Waite and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. Peer reviewer reports are available.
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Supplementary Material 1. The distribution of participants per sexual and gender diverse categories per region and per age. Supplementary Material 2. A comparative analysis of LGBTQ+ life satisfaction across regions. Supplementary Material 3. A study of LGBTQ+ participants’ subjective well-being with that of the general population. Supplementary Material 4. The association between the three dimensions of homophobia and subjective well-being by sexual identity and by region. Supplementary Material 5. Regressions clustered by the level of economic precarity of LGBTQ+ participants. Supplementary Material 6. An analysis of the association between well-being and economic precarity, by Gini index. Supplementary Material 7. A sensitivity analysis of the happiness index. Supplementary Material 8. Comparison of a subsample of countries with the European MSM Internet Survey (2017). Supplementary Material 9. Preregression tests.
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Lamontagne, E., Leroy, V., Howell, S. et al. Homophobia, economic precarity and the well-being of sexual and gender diverse people in a 153-country survey. Nat Hum Behav (2025). https://doi.org/10.1038/s41562-025-02361-9
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DOI: https://doi.org/10.1038/s41562-025-02361-9


