Extended Data Fig. 8: Extravasation dynamics of paired human tumour cell lines support link between viscosity and endothelial remodeling-driven extravasation.
From: Cell viscosity influences haematogenous dissemination and metastatic extravasation of tumour cells
a, Heatmaps displaying hotspots of intravascular, pocketed and extravasated patient-derived tumour cells 24 hpi. (N = 2 (All cell lines), n (embryos) = 39 (MCF-7), 55 (MDA-MB-231), 40 (M229R), 29 (M229S, CTC-45), 26 (CPP-45)). b, Ratio of pocketed cells 24 hours post-injection of MCF-7 vs MDA-MB-231 tumour cells. (N = 2 (MCF-7, MDA-MB-231), n (embryos) = 39 (MCF-7), 55 (MDA-MB-231)) (Two-tailed Mann-Whitney). c, Ratio of extravasated cells 24 hpi of M229 R vs M229 S tumour cells. (N = 2 (M229 R, M229 S), n (embryos) = 40 (M229 R), 29 (M229 S)) (Two-tailed Mann-Whitney). d, CPP-45 tumour cells arrested in ZF embryo 24 hpi. Yellow arrows indicate extravasated cells. e, Ratio of extravasated cells 24 hpi of CTC-45 vs CPP-45 tumour cells. (N = 2 (CTC-45, CPP-45), n (embryos) = 29 (CTC-45), 25 (CPP-45)) (Two-tailed Mann-Whitney). Data are presented as mean +/- standard deviation in b-c and e.
