Extended Data Fig. 8: Schematic model to show IFI16 enhances RIG-I signaling in influenza virus infection. | Nature Microbiology

Extended Data Fig. 8: Schematic model to show IFI16 enhances RIG-I signaling in influenza virus infection.

From: IFI16 directly senses viral RNA and enhances RIG-I transcription and activation to restrict influenza virus infection

Extended Data Fig. 8: Schematic model to show IFI16 enhances RIG-I signaling in influenza virus infection.

Briefly, influenza virus infection upregulates IFI16 expression; IFI16 protein, in turn, enhances transcription of RIG-I. In addition, IFI16 protein, via its HINa domain, directly senses viral RNA and, via its PYRIN domain, interacts with RIG-I receptor to promote antiviral RIG-I signaling.

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