Extended Data Fig. 2: Biochemical and histological markers of inflammation were elevated in HCVi compared to SVR. | Nature Microbiology

Extended Data Fig. 2: Biochemical and histological markers of inflammation were elevated in HCVi compared to SVR.

From: Longitudinal multi-omics analyses of the gut–liver axis reveals metabolic dysregulation in hepatitis C infection and cirrhosis

Extended Data Fig. 2: Biochemical and histological markers of inflammation were elevated in HCVi compared to SVR.

Wilcoxon matched pairs signed rank test, two-sided unadjusted p-value. Compared to SVR, HCVi patients had elevated serum markers of hepatocellular inflammation (ALT, alanine aminotransferase p < 0.0001; AST, aspartate aminotransferase p < 0.0001; GGT, gamma-glutamyl transferase p = 0.0001); histological marker of inflammation (HAI, Hepatic Activity index) p < 0.0001; and elevated serum total bilirubin p = 0.0010. HCVi showed no significant difference in fibrosis p = 0.2483, direct portal pressures p = 0.8175, or alkaline phosphatase p = 0.1172. Scatter plots with bars, data is presented as median values + /- IQR. n = 22.

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