Extended Data Fig. 6: Lung IL-1β, IL-6, GM-CSF, and TNF-α levels from ΔppsD Mtb infected mice were elevated in Atg5, Atg7, and Atg14 cKO mice and not significantly impacted by Nox2 or Rbcn. | Nature Microbiology

Extended Data Fig. 6: Lung IL-1β, IL-6, GM-CSF, and TNF-α levels from ΔppsD Mtb infected mice were elevated in Atg5, Atg7, and Atg14 cKO mice and not significantly impacted by Nox2 or Rbcn.

From: Mycobacterium tuberculosis virulence lipid PDIM inhibits autophagy in mice

Extended Data Fig. 6

(a-e) Indicated mouse strains were infected by aerosol with low dose ΔppsD Mtb as described in Fig. 3. Cytokine levels in lung homogenates of ΔppsD Mtb-infected (a) Atg5 cKO, (b) Atg7 cKO, (c) Atg14 cKO, (d) Nox2 KO and (e) Rbcn KO 14 dpi. Each data point represents one mouse; n = 5 for Atg5 and Atg7; n = 6 for Atg14 and Rbcn; n = 10 for Nox2 mice per group; data show the mean ± SEM; unpaired two-tailed t test.

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