Extended Data Fig. 3: Inhibiting DegS is a viable strategy to treat VIM-2-expressing K. pneumoniae in vivo.
Viable cell counts of K. pneumoniae carrying the empty vector (Empty) or expressing VIM-2 (VIM-2) in the (a) blood, (b) kidney, and (c) liver. Each strain was treated with a vehicle (grey; blood n = 5,5; kidney n = 7,6, liver n = 7,7) or 50 mg/kg of the DegS inhibitor (orange; blood n = 4,8, kidney n = 6,8, liver n = 6,10) one hour after infection. Each point represents an individual mouse. The centre line delineates the median, the box limits mark the upper and lower quartiles, and the whiskers depict the range. CFU were enumerated at 6 hours post-infection. Statistical analysis was performed using a two-sided Mann-Whitney test with Benjamini, Krieger and Yekutieli’s multiple comparisons test, *P < 0.05, **P < 0.01. The mouse infection model was repeated on three separate days.
