Extended Data Fig. 3: Association of Phocaeicola vulgatus with kidney function.
The data represented the AST-transformed relative abundance of P. vulgatus across participants with different kidney disease severity in the RLAS cohort, HS study, and published dataset. P values for the group difference were tested by MaAsLin2 (two-sided test) with the adjustment of age, sex, body mass index, diabetes, hypertension, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol in the HS study, and further adjusted for cancer and medication use in the RLAS cohort. The Benjamini-Hochberg method was used to calculate FDR-adjusted P values only in the RLAS cohort. The boxes represented the median and interquartile range (IQR) of the distributions, and top and bottom whiskers marked the point at 1.5×IQR. Participants of eGFR ≥ 90 mL/min/1.73 m2, n = 187; Participants of eGFR ≥ 60 & < 90 mL/min/1.73 m2, n = 1,035; Participants of eGFR < 60 mL/min/1.73 m2, n = 328. Participants in HS study: control, n = 15; CKD, n = 47; KF, n = 52. Participants in the published dataset: control, n = 69; KF, n = 223. ns, not significant (P > 0.05). eGFR, estimated glomerular filtration rate; CKD, chronic kidney disease; KF, kidney failure.
