Extended Data Fig. 10: Schematic showing the potential role of DSC2 in mediating EBV infection. | Nature Microbiology

Extended Data Fig. 10: Schematic showing the potential role of DSC2 in mediating EBV infection.

From: Desmocollin 2 is a dominant entry receptor for Epstein–Barr virus infection of epithelial cells

Extended Data Fig. 10: Schematic showing the potential role of DSC2 in mediating EBV infection.

DSC2 is the dominant entry receptor for EBV infection in epithelial cells. The gene deletion of DSC2 resulted in the inability of EBV-susceptible epithelial cells to be infected by EBV even in the presence of EphA2 (left panel). Upregulation of DSC2 could still effectively mediate EBV infection in EPHA2 knockout EBV-susceptible epithelial cells (middle panel). Moreover, ectopic expression of human DSC2 enabled the cells to acquire susceptibility to EBV in non-EBV-susceptible cells (right panel). This figure was created with BioRender.com.

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