Extended Data Fig. 7: Haplotype Distribution of Passages and Stock of Hemagglutinin.

Phylogenetic relationships of hemagglutinin haplotypes derived from passages and stock, along with their corresponding Log10 frequency percentages. The tree was constructed using the maximum likelihood method with 1,000 bootstrap replicates, and branches with a bootstrap support of 65 or higher are indicated with thicker lines. The labels indicate the following: N = passages without mAb, S = stock, 12D03 = passages with 310-12D03, 74 = passages with 326-289.84. The alignment highlights nucleotide changes, with positions annotated using the H3 codon annotation.