Extended Data Fig. 8: In vivo protection comparing combinations and individual mAbs.
a, b, Protection and maximum weight change (%) upon H5 TX/24 challenge after passive transfer of combinations of mAbs (total 0.6 mg/kg) and individual mAbs at 0.6 mg/kg (a) or 0.3 mg/kg (b). Data shown for individual mAbs is same as in Fig. 3. Statistical significance of survival was determined by log-rank (Mantel-Cox) test with Bonferroni-Sidak adjustment. All mAb combinations were statistically significant relative to VRC01 (p < 0.001); p = 0.0002 for 310-7D11 + 310-12D03, p = 0.0006 for 310-12D03 + MEDI8852, p = 0.0008 for 310-7D11 + MEDI8852, p = 0.0002 for 310-7D11 + 310-12D03 + MEDI8852. There was no significant difference in survival between combinations and individual mAbs at 0.6 mg/kg. All combinations except 310-12D03 + MEDI88252 were statistically more protective than individual mAbs at 0.3 mg/kg. For comparisons against 310-7D11 0.3 mg/kg, p = 0.0032 for 310-7D11 + 310-12D03, p = 0.0102 for 310-7D11 + MEDI8852, p = 0.0008 for 310-7D11 + 310-12D03 + MEDI8852. For comparisons against 310-12D03 0.3 mg/kg, p = 0.011 for 310-7D11 + 310-12D03 and p = 0.0055 for 310-7D11 + 310-12D03 + MEDI8852. For comparisons against MEDI8852 0.3 mg/kg, p = 0.0015 for 310-7D11 + 310-12D03, p = 0.0058 for 310-7D11 + MEDI8852, p = 0.0028 for 310-12D03 + MEDI8852, and p = 0.0007 for 310-7D11 + 310-12D03 + MEDI8852.
