Extended Data Table 2 Characteristics of top 5 mAbs
310-12D03 | 310-1H02 | 310-7D11 | 310-289.74 | 310-366.26 | MEDI8852 | |
|---|---|---|---|---|---|---|
VH | VH4-61 | VH3-15 | VH3-33 | VH1-69 | VH4-4 | |
VH SHM (%) | 5.5 | 4.4 | 3.8 | 4.5 | 6.9 | |
CDRH3 | ATSYITGIQGVDY | TTLYCAITTCFSPRY | ARDGFPNCISATCGYAMDV | ARDQYSNYFYGLDV | ARGLGWEQGGYRAFDM | |
VK/L | VK3-20 | VL2-23 | VK2-28 | VK3-11 | VK3-15 | |
VK/L SHM (%) | 1.5 | 2.6 | 2.9 | 2.5 | 2.5 | |
CDRL3 | QQYGYSLTWT | CSYVGSDTWGV | MQGLETPFT | QQRSNWPPLYS | QQHYNWPPLT | |
H5 TX/24 IC80 | 0.007 | 0.02 | 0.006 | 0.017 | 0.013 | 0.124 |
H5 Sich/14 IC80 | 0.001 | 0.006 | 0.013 | 0.006 | 0.008 | 0.036 |
H5 Cam/23 IC80 | 0.002 | 0.273 | 0.01 | 0.133 | >25 | 0.328 |
H5 Vict/24 IC80 | 0.749 | 0.067 | >25 | 0.335 | 0.193 | 0.742 |
H5 Indo/05 IC80 | 0.001 | 0.005 | 0.004 | 0.014 | 0.009 | 0.177 |
H5 Viet/04 IC80 | >25 | >25 | 0.008 | 0.022 | 0.012 | 0.214 |
H2 Sing/57 IC80 | >25 | >25 | >25 | >25 | 0.135 | 0.267 |
H5 Mex/24 IC80 | 0.006 | 0.221 | 1.884 | >25 | >25 | 0.955 |
