Fig. 4: Targeting mitochondrial cytochrome bc1 enhances AMB susceptibility.
From: Candida auris skin tropism and antifungal resistance are mediated by carbonic anhydrase Nce103
a, Deletion of RIP1 encoding the active subunit of the cytochrome bc1 complex increases AMB susceptibility. MIC assays were performed for C. auris in RPMI, YPD and YP–2% glycerol (YPG). b, The cytochrome bc1 inhibitor Inz-5 partially phenocopies the sensitivity of the rip1∆ mutant in a serial dilution spotting assay, in both the presence and absence of AMB. c, Inz-5 reduces the AMBMIC by about 2- to 4-fold across multiple fungal pathogens in checkerboard assays. Two to three biological replicates were performed in a–c.
