Table 3 Neurovirulence of the double recombinant nOPV2 strain from Kabarole in transgenic mice compared with type 2 vaccine, revertant and wild-type poliovirus strains

From: Higher stability of novel live-attenuated oral poliovirus type 2 (nOPV2) despite the emergence of a neurovirulent double recombinant strain in Uganda

Virus strain

PD50 (log10)

nOPV2 (vaccine strain)

>8.4

Sabin 2 (vaccine strain)

5.8 (5.1–6.4)

S2/481G (Sabin 2 revertant strain)

1.8 (1.4–2.2)

ENV-UGA-KAB-KAB-KIS-22-004 (Kabarole double recombinant strain)

1.1 (0.6–1.6)

MEF-1 (wild-type 2 strain)

0.7 (0.2–1.2)

  1. Transgenic mice expressing the poliovirus receptor (minimum n = 8 biologically independent mice per dilution) were inoculated intraspinally with stocks of representative poliovirus strains. The PD50 was calculated using the Spearman–Karber method. Data are presented as PD50 values with 95% CI.
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