Extended Data Table 2 Number of nOPV2 isolates with different combinations of mutations reducing attenuation of the virus

From: Higher stability of novel live-attenuated oral poliovirus type 2 (nOPV2) despite the emergence of a neurovirulent double recombinant strain in Uganda

Total_mutations

No. of isolates

C121T

T123C

G147A

G179A

A181G

Deletion_179_183

G196A

G196del

A215T

T217C

G322A

T459C

VP1-I143T/V/N/S

VP1-N171D

5

1

 

  

 

    

 

4

13

   

      

 

4

6

 

     

   

 

4

4

 

  

      

 

4

3

 

       

 

 

4

1

   

      

 

4

1

   

     

 

 

4

1

 

      

  

 

4

1

 

        

 

4

1

  

       

 

3

37

 

         

 

3

8

 

     

    

 

3

7

   

       

 

3

5

   

       

 

3

2

    

      

 

3

2

   

   

    

 

3

2

 

    

     

 

3

2

 

  

       

 

3

1

     

     

 

3

1

 

        

 

 

3

1

 

       

  

 

2

37

 

          

 

2

11

       

    

 

2

10

   

        

 

2

4

 

         

  

2

1

           

 

2

1

   

         

2

1

   

       

  

2

1

   

     

    

1

17

 

            

1

14

            

 

1

7

   

          

1

1

             

1

1

           

  

1

1

         

    

0

24

              

TOTAL

231

1

126

1

51

28

1

3

27

1

7

3

87

175

2