Extended Data Fig. 7: Titers of tryptophan-derived metabolites in hemolymph of P. stali infected with different E. coli strains.
From: Tryptophanase disruption promotes insect–bacterium mutualism
(a) A schematic overview of tryptophan metabolism. Compounds quantified by LC-MS are highlighted in bold. Red, blue and black represent metabolites that increased, decreased and unchanged by infection with the host performance-improving E. coli mutants (CmL05G13, ΔcyaA and ΔtnaA), respectively. (b-k) Titers of tryptophan and its derived metabolites in the host hemolymph. (b) Tryptophan (Trp). (c) Indole. (d) 5-Hydroxytryptophan (5HTrp). (e) Hydroxyindoleacetate (HIAA). (f) Kynurenine (Kyn). (g) 3-Hydroxykynurenine (3HK). (h) Xanthurenic acid (XA). (i) Indole-3-acetic acid (IAA). (j) Indole-3-carboxylic acid (ICA). (k) Indole-3-ethanol (IEt). Other abbreviations: 3HAA, 3-Hydroxyanthranilic acid; CA, Cinnabarinic acid; 5HT, 5-Hydroxytryptamine; IAM, Indole-3-acetamide; IAAId, Indole-3-acetaldehyde; IGA, Indole-3-glyoxicacid. For box plots, center lines, limits, and dots show medians, first and third quartiles, and data points. Different alphabetical letters (a-d) indicate statistically significant differences (pairwise Wilcoxon rank-sum test with Hommel’s correction: P < 0.05, two-sided). The exact P-values are provided in the source data file.
