Extended Data Fig. 4: HTPBDTRAP1 + 5-FU treatment effectively modulates the tumour immune microenvironment.
From: An orally administered gene editing nanoparticle boosts chemo-immunotherapy in colorectal cancer
a-e, Representative FCM plots and quantitative statistical analysis of DCs (CD80+CD86+ in CD11c+) in mesenteric lymph nodes (a), CD8+ cytotoxic T cells (CD8+ in CD3+) (b), Tregs (CD4+Foxp3+ in CD3+) (c), MDSCs (CD11b+Gr-1+) (d) or CD4+ helper T cells (CD4+ in CD3+) (e) in CRC tumour tissues after different treatments. n = 4 independent samples. f,g, The levels of IFN-γ, TNF-α (f), IL-6 and IL-12p70 (g) in CRC tumour tissues of different treatment groups were determined by ELISA. n = 4 independent samples. Data are presented as mean ± s.d. Statistical significance was determined by one-way ANOVA with Tukey’s post hoc corrections (a-g).
