Extended Data Fig. 2: Multi-therapeutic properties of C’ dot adjuvants lead to diverse responses in the TME of melanoma models. | Nature Nanotechnology

Extended Data Fig. 2: Multi-therapeutic properties of C’ dot adjuvants lead to diverse responses in the TME of melanoma models.

From: An ultrasmall core–shell silica nanoparticle improves antitumour immunity and survival by remodelling suppressive melanoma microenvironments

Extended Data Fig. 2: Multi-therapeutic properties of C’ dot adjuvants lead to diverse responses in the TME of melanoma models.

A diverse array of proinflammatory and cytotoxic responses (upper left) promoted by C’ dots are illustrated, in addition to their induction of cell cycle arrest and senescence (SASP) (upper right). Inhibition of resistance mechanisms in the TME driving upregulation of suppressive cell populations and proteins are shown (lower left) along with factors improving anti-tumor immunity (lower right). Schematic created with BioRender.com.

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