Extended Data Fig. 10: The sequence-structure analysis of the interacting interface between ATAT-2 and microtubules. | Nature Physics

Extended Data Fig. 10: The sequence-structure analysis of the interacting interface between ATAT-2 and microtubules.

From: Tubulin isotypes of C. elegans harness the mechanosensitivity of the lattice for microtubule luminal accessibility

Extended Data Fig. 10: The sequence-structure analysis of the interacting interface between ATAT-2 and microtubules.The alternative text for this image may have been generated using AI.

(a and b) Primary sequence alignment of MEC-12 and TBA-2 (a) and MEC-7 and TBB-2 (b). The residues of MEC-12 and MEC-7 that interact with ATAT-2 are highlighted in bold font. The ATAT-2 interacting residues divergent between these tubulin isotypes are italicized and underlined. (c) The ATAT-2 interacting residues are mapped onto the luminal surface of MEC-12/MEC-7 microtubules (PDB 8Y9F). The interacting residues that are identical and divergent between MEC-12/TBA-2 and MEC-7/TBB-2 are highlighted in pink and orange, respectively. The taxane-binding pockets and the α-tubulin H1-S2 loop (the K40 loop) are indicated.

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