The 2021 American Heart Association scientific statement on the ‘mind–heart–body connection’ brought psychological health on to the cardiovascular stage. A new 2025 European Society of Cardiology clinical consensus statement advances this field, translating concepts into operational pathways with screening algorithms, stepped care and pharmacotherapy guidance. Together, these recommendations mark a pivotal shift, moving from why mental health matters in cardiology to how it can be systematically delivered in practice.
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References
Levine, G. N. et al. Psychological health, well-being, and the mind-heart-body connection: a scientific statement from the American Heart Association. Circulation 143, e763–e783 (2021).
Kroenke, K., Spitzer, R. L. & Williams, J. B. The Patient Health Questionnaire-2: validity of a two-item depression screener. Med. Care 41, 1284–1292 (2003).
Plummer, F., Manea, L., Trepel, D. & McMillan, D. Screening for anxiety disorders with the GAD-7 and GAD-2: a systematic review and diagnostic metaanalysis. Gen. Hosp. Psychiatry 39, 24–31 (2016).
Linden, W., Phillips, M. J. & Leclerc, J. Psychological treatment of cardiac patients: a meta-analysis. Eur. Heart J. 28, 2972–2984 (2007).
Blumenthal, J. A. et al. Effects of exercise and stress management training on markers of cardiovascular risk in patients with ischemic heart disease: a randomized controlled trial. JAMA 293, 1626–1634 (2005).
Bueno, H. et al. 2025 ESC Clinical Consensus Statement on mental health and cardiovascular disease: developed under the auspices of the ESC Clinical Practice Guidelines Committee. Eur. Heart J. 46, 4156–4225 (2025).
Abohashem, S. et al. Imaging findings associated with socioenvironmental exposures inform mechanisms of cardiovascular disease. Arterioscler. Thromb. Vasc. Biol. https://doi.org/10.1161/ATVBAHA.125.322470 (2025).
Ziegler, K. A. et al. Neural mechanisms in cardiovascular health and disease. Circ. Res. 136, 1233–1261 (2025).
Ski, C. F. et al. Psychological interventions for depression and anxiety in patients with coronary heart disease, heart failure or atrial fibrillation. Cochrane Database Syst. Rev. 4, CD013508 (2024).
Acknowledgements
O.H. is supported by the environmental network EXPOHEALTH (funded by the Science Initiative of the state Rhineland-Palatinate, Germany) and by the environmental research consortium MARKOPOLO (funded by the European Union (Grant Agreement Number 101156161) and the Swiss State Secretariat for Education, Research and Innovation). S.A. is supported in part by the American Heart Association (AHA) Second Century Early Faculty Independence Award (#24SCEFIA1256969) and AHA’s Transformational Project Award (#25TPA1474746).
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Hahad, O., Abohashem, S. Integration of cardiovascular and mental health: from concepts to the clinic. Nat Rev Cardiol 23, 1–3 (2026). https://doi.org/10.1038/s41569-025-01231-1
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DOI: https://doi.org/10.1038/s41569-025-01231-1