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Bone fragility in type 2 diabetes mellitus: a lot left to explore

Nature Reviews Endocrinology volume 18, page 651 (2022)Cite this article

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We read with interest the narrative Review by Khosla et al. (Khosla, S., Samakkarnthai, P., Monroe, D. G. & Farr, J. N. Update on the pathogenesis and treatment of skeletal fragility in type 2 diabetes mellitus. Nat. Rev. Endocrinol. 17, 685–697 (2021))1. The authors have clearly elucidated the aetiopathogenesis of diabetic bone disease; nevertheless, certain aspects of the disease deserve further thought, especially when it comes to diagnosis and management of bone fragility in type 2 diabetes mellitus (T2DM).

The fact that bone mineral density (BMD) is higher in people with T2DM than in age-matched and sex-matched healthy individuals is not universally applicable. Most of the data with regard to BMD in people with T2DM is based on the white population. Similar data from Asia, where the majority of the global population of people with T2DM reside, are scarce. As an example, available data from India suggests that BMD is highly variable in people with T2DM; in fact, BMD in people with T2DM was observed to be lower than in healthy individuals in some studies2,3.

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References

  1. Khosla, S., Samakkarnthai, P., Monroe, D. G. & Farr, J. N. Update on the pathogenesis and treatment of skeletal fragility in type 2 diabetes mellitus. Nat. Rev. Endocrinol. 17, 685–697 (2021).

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Authors and Affiliations

  1. Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

    Rimesh Pal, Trupti N. Prasad & Sanjay K. Bhadada

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  1. Rimesh Pal
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  2. Trupti N. Prasad
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  3. Sanjay K. Bhadada
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Correspondence to Sanjay K. Bhadada.

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Pal, R., Prasad, T.N. & Bhadada, S.K. Bone fragility in type 2 diabetes mellitus: a lot left to explore. Nat Rev Endocrinol 18, 651 (2022). https://doi.org/10.1038/s41574-022-00707-1

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