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Promising drugs for PCOS: targeting metabolic and endocrine dysfunctions

Emerging pharmaceuticals that target metabolic and endocrine dysfunctions in polycystic ovary syndrome are transforming treatment paradigms. This article covers innovative drugs, including glucagon-like peptide 1 receptor agonists, sodium–glucose cotransporter 2 inhibitors, kisspeptin, neurokinin 3 receptor antagonists and artemisinins, exploring their mechanisms and potential to advance care for this disorder.

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Fig. 1: Potential beneficial effects of pharmacological interventions on reproductive and metabolic outcomes in PCOS treatment.

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Acknowledgements

The authors are supported by the National Natural Science Foundation of China (82471670) and the National Science and Technology Council (NSTC 113-2314-B-039-055).

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Correspondence to Jingjing Jiang, Yue Zhao, Hsun-Ming Chang or Liangshan Mu.

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The authors declare no competing interests.

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Zhou, K., Lou, C., Chang, PH. et al. Promising drugs for PCOS: targeting metabolic and endocrine dysfunctions. Nat Rev Endocrinol 21, 455–456 (2025). https://doi.org/10.1038/s41574-025-01121-z

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