Although enhancers activate transcription from long distances, they stimulate transcription only through short-range interactions with the RNA polymerase II machinery. I posit that action at a distance is mediated by loops between distal and proximal enhancers that thereby bring proteins associated with distal enhancers near promoters.
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Struhl, K. Distal enhancers loop to proximal enhancers, not to promoters. Nat Rev Mol Cell Biol 26, 730–731 (2025). https://doi.org/10.1038/s41580-025-00889-2
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DOI: https://doi.org/10.1038/s41580-025-00889-2
