Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Comment
  • Published:

Menopause and chronic kidney disease

Nature Reviews Nephrology volume 20, pages 4–5 (2024)Cite this article

Subjects

Chronic kidney disease (CKD) is highly prevalent in women in perimenopause and menopause. Both CKD and menopause affect several important pathologies, such as cardiovascular disease (CVD) and bone mineral disease. More research is needed to better understand the relationships between menopause, CKD, CVD and bone disease.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Bidirectional relationship between chronic kidney disease and menopause.

References

  1. Vellanki, K. & Hou, S. Menopause in CKD. Am. J. Kidney Dis. 71, 710–719 (2018).

    Article  PubMed  Google Scholar 

  2. Takahashi, T. A. & Johnson, K. M. Menopause. Med. Clin. North Am. 99, 521–534 (2015).

    Article  PubMed  Google Scholar 

  3. K/DOQI Workgroup. K/DOQI clinical practice guidelines for cardiovascular disease in dialysis patients. Am. J. Kidney Dis. 45 (Suppl. 3), S1–S153 (2005).

    Google Scholar 

  4. Ahmed, S. B., Vitek, W. S. & Holley, J. L. Fertility, contraception, and novel reproductive technologies in chronic kidney disease. Semin. Nephrol. 37, 327–336 (2017).

    Article  PubMed  Google Scholar 

  5. Holley, J. L., Schmidt, R. J., Bender, F. H., Dumler, F. & Schiff, M. Gynecologic and reproductive issues in women on dialysis. Am. J. Kidney Dis. 29, 685–690 (1997).

    Article  CAS  PubMed  Google Scholar 

  6. Honigberg, M. C. et al. Association of premature natural and surgical menopause with incident cardiovascular disease. J. Am. Med. Assoc. 322, 2411–2421 (2019).

    Article  Google Scholar 

  7. Qian, D. et al. Early menopause may associate with a higher risk of CKD and all-cause mortality in postmenopausal women: an analysis of NHANES, 1999–2014. Front. Med. (Lausanne) 9, 823835 (2022).

    Article  PubMed  Google Scholar 

  8. Pazianas, M. & Miller, P. D. Osteoporosis and chronic kidney disease-mineral and bone disorder (CKD-MBD): back to basics. Am. J. Kidney Dis. 78, 582–589 (2021).

    Article  CAS  PubMed  Google Scholar 

  9. Ketteler, M. et al. Executive summary of the 2017 KDIGO chronic kidney disease-mineral and bone disorder (CKD-MBD) guideline update: what’s changed and why it matters. Kidney Int. 92, 26–36 (2017).

    Article  PubMed  Google Scholar 

  10. Cheung, K. L. et al. Menopausal symptoms in women with chronic kidney disease. Menopause 22, 1006–1011 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA

    Virginia A. Dines & Vesna D. Garovic

  2. Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA

    Vesna D. Garovic

Authors
  1. Virginia A. Dines
    View author publications

    Search author on:PubMed Google Scholar

  2. Vesna D. Garovic
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Vesna D. Garovic.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dines, V.A., Garovic, V.D. Menopause and chronic kidney disease. Nat Rev Nephrol 20, 4–5 (2024). https://doi.org/10.1038/s41581-023-00717-w

Download citation

  • Published:

  • Version of record:

  • Issue date:

  • DOI: https://doi.org/10.1038/s41581-023-00717-w

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing