Table 4 Physicochemical properties and clearance of drugs by extracorporeal blood purification techniques

Drug				Estimated clearance by extracorporeal blood purification^a				Refs.
Name	Molecular weight	Protein binding	Volume of distribution	CRRT^b	Plasma exchange^c	Intermittent haemodialysis^d	Peritoneal dialysis	Refs.
Cisplatin	300 Da	>90%	20–80 l/m²	Not cleared	70%	Not cleared	Not cleared	^171,172
Methotrexate	454 Da	46%	1 l/kg	37%	70%	70%	Unknown
Gemcitabine	263 Da	<10%	0.82 l/kg	37%	70%	70%	Unknown
Pazopanib	437 Da	>99%	11 l (0.16 l/kg)	Not cleared	70%	Not cleared	Unknown
Pembrolizumab	149 kDa	NA	3.2 l (0.05 l/kg)	Not cleared	70%	Not cleared	Unknown

CRRT, continuous renal replacement therapy; NA, not available. ^aClearance estimates are based on the physicochemical properties of each drug. ^bPercentage clearance based on effluent rate of 25 ml/kg/h over 24 h, which yields a Kt/V of 1. ^cPercentage clearance based on total plasma volume exchange of 1.5. ^dPercentage clearance based on single pool Kt/V of 1.4.

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