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Selective neuronal loss could limit penumbral rescue after stroke

Nature Reviews Neurology volume 14, pages 380–381 (2018) Cite this article

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Reperfusion therapies have transformed the therapeutic landscape for acute ischaemic stroke, but functional outcomes are still suboptimal in many patients. To address this issue, investigators have turned their attention to the penumbra — that is, the potentially salvageable brain tissue surrounding the ischaemic core. In a new study, Jean-Claude Baron and colleagues have shown that penumbral tissue rescued from impending infarction by reperfusion therapies is not intact and exhibits selective neuronal loss (SNL) that might be targeted therapeutically to enhance functional recovery.

The new study, reported in Brain, was prompted by previous research in rat models of stroke, which found SNL in association with microglial activation in salvaged penumbral tissue. “The idea was to see whether we could also demonstrate SNL and microglial activation in the rescued penumbra in humans and, if so, whether they were closely associated, as in rats,” explains Baron.

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  1. Nature Reviews Neurology http://www.nature.com/nrneurol/

    Heather Wood

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  1. Heather Wood
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Correspondence to Heather Wood.

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Wood, H. Selective neuronal loss could limit penumbral rescue after stroke. Nat Rev Neurol 14, 380–381 (2018). https://doi.org/10.1038/s41582-018-0015-x

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