Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

CNS INFECTIONS

Meningeal lymphatics mediate drainage of viruses from the CNS

Nature Reviews Neurology volume 18, page 382 (2022)Cite this article

Subjects

Neurotropic viruses can spread to the periphery via meningeal lymphatic vessels (MLVs), according to new work published in Nature Neuroscience. The study also found that functionally expanding MLVs can improve the outcome of a CNS infection, suggesting that this mechanism could be targeted therapeutically.

“Previous studies of viral dissemination focused on the blood–brain barriers or the blood–CSF barrier,” notes Hongyang Wang, who led the study with Bin Wei. “However, no reports are available about the role and changes of MLVs during neurotropic virus infection.”

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

References

Original article

  • Li, X. et al. Meningeal lymphatic vessels mediate neurotropic viral drainage from the central nervous system. Nat. Neurosci. 25, 577–587 (2022)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Nature Reviews Neurology http://www.nature.com/nrneurol/

    Sarah Lemprière

Authors
  1. Sarah Lemprière
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Sarah Lemprière.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lemprière, S. Meningeal lymphatics mediate drainage of viruses from the CNS. Nat Rev Neurol 18, 382 (2022). https://doi.org/10.1038/s41582-022-00677-y

Download citation

  • Published:

  • Version of record:

  • Issue date:

  • DOI: https://doi.org/10.1038/s41582-022-00677-y

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing