Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Migraine

Continuing evolution of migraine-specific therapies — targeting migraine with precision and persistence

Subjects

Treatment options for migraine have expanded rapidly over the past few years. The latest success in a phase II trial of a new class of drugs for migraine holds the promise of another alternative, with important implications for our understanding of migraine and its clinical management.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Ashina, M., Phul, R., Khodaie, M., Löf, E. & Florea, I. A monoclonal antibody to PACAP for migraine prevention. N. Engl. J. Med. 391, 800–809 (2024).

    Article  CAS  PubMed  Google Scholar 

  2. Mitsikostas, D. D. et al. The 5-HT1F receptor as the target of ditans in migraine — from bench to bedside. Nat. Rev. Neurol. 19, 489–505 (2023).

    Article  PubMed  Google Scholar 

  3. Edvinsson, L., Haanes, K. A., Warfvinge, K. & Krause, D. N. CGRP as the target of new migraine therapies — successful translation from bench to clinic. Nat. Rev. Neurol. 14, 338–350 (2018).

    Article  CAS  PubMed  Google Scholar 

  4. Ashina, H. et al. Pituitary adenylate cyclase-activating polypeptide signalling as a therapeutic target in migraine. Nat. Rev. Neurol. https://doi.org/10.1038/s41582-024-01011-4 (2024).

  5. Schytz, H. W. et al. PACAP38 induces migraine-like attacks in patients with migraine without aura. Brain 132, 16–25 (2009).

    Article  PubMed  Google Scholar 

  6. Ashina, M. et al. A phase 2, randomized, double-blind, placebo-controlled trial of AMG 301, a pituitary adenylate cyclase-activating polypeptide PAC1 receptor monoclonal antibody for migraine prevention. Cephalalgia 41, 33–44 (2021).

    Article  PubMed  Google Scholar 

  7. Rasmussen, N. B. et al. The effect of Lu AG09222 on PACAP38- and VIP-induced vasodilation, heart rate increase, and headache in healthy subjects: an interventional, randomized, double-blind, parallel-group, placebo-controlled study. J. Headache Pain 24, 60 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Vollesen, A. L. H. et al. The effect of pituitary adenylate cyclase-activating peptide-38 and vasoactive intestinal peptide in cluster headache. Cephalalgia 40, 1474–1488 (2020).

    Article  PubMed  Google Scholar 

  9. Al-Khazali, H. M. et al. Hypersensitivity to PACAP-38 in post-traumatic headache: a randomized clinical trial. Brain 147, 1312–1320 (2024).

    Article  PubMed  Google Scholar 

  10. Igarashi, H. et al. Underrecognition of migraine-related stigmatizing attitudes and social burden: results of the OVERCOME Japan study. Brain Behav. 14, e3547 (2024).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Dimos D. Mitsikostas.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mitsikostas, D.D., Rapoport, A. Continuing evolution of migraine-specific therapies — targeting migraine with precision and persistence. Nat Rev Neurol 20, 645–646 (2024). https://doi.org/10.1038/s41582-024-01026-x

Download citation

  • Published:

  • Version of record:

  • Issue date:

  • DOI: https://doi.org/10.1038/s41582-024-01026-x

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing