Previous investigations of the genome of Wilms tumour have demonstrated surprisingly few driver mutations and low tumour mutational burden. Integrating duplex sequencing and use of laser-captured specimens and tumour organoids unveiled a fourfold increased tumour mutational burden and a new vision of clonal architecture in infant Wilms tumour.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$32.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Gadd, S. et al. A Children’s Oncology Group and TARGET initiative exploring the genetic landscape of Wilms tumor. Nat. Genet. 49, 1487–1494 (2017).
Gröbner, S. N. et al. The landscape of genomic alterations across childhood cancers. Nature 555, 321–327 (2018).
Thatikonda, V. et al. Comprehensive analysis of mutational signatures reveals distinct patterns and molecular processes across 27 pediatric cancers. Nat. Cancer 4, 276–289 (2023).
Sha, D. et al. Tumor mutational burden as a predictive biomarker in solid tumors. Cancer Discov. 10, 1808–1825 (2020).
Budczies, J. et al. Tumour mutational burden: clinical utility, challenges and emerging improvements. Nat. Rev. Clin. Oncol. 21, 725–742 (2024).
Lee-Six, H. et al. High resolution clonal architecture of hypomutated Wilms tumours. Nat. Commun. 16, 4647 (2025).
Schmitt, M. W. et al. Detection of ultra-rare mutations by next-generation sequencing. Proc. Natl Acad. Sci. USA 109, 14508–14513 (2012).
Tsai, J. W. et al. FOXR2 is an epigenetically regulated pan-cancer oncogene that activates ETS transcriptional circuits. Cancer Res. 82, 2980–3001 (2022).
Gillani, R. et al. Rare germline structural variants increase risk for pediatric solid tumors. Science 387, eadq0071 (2025).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Hong, A.L., Mullen, E.A. Finding a brush when you expect a broom: a novel model of paediatric Wilms tumour evolution. Nat Rev Urol (2025). https://doi.org/10.1038/s41585-025-01082-y
Published:
Version of record:
DOI: https://doi.org/10.1038/s41585-025-01082-y
