Extended Data Fig. 3: FGF locus 4C-seq data and insulator deletion.
From: Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs
a, Traces depict 4C-seq data at FGF locus, as in Fig. 2b, except graphed on the same axis to allow for direct comparison. b, c, Bar plots quantify 4C-seq interactions between the super-enhancer viewpoint and FGF4 (b) or FGF3 (c). Expression of these genes in the corresponding SDH-deficient GIST specimens is also shown. d, Traces depict CTCF ChIP–seq signal in GIST-T1 cells infected with CRISPR–Cas9 and either a control sgRNA directed at GFP (black, top) or sgRNAs directed against the two indicated CTCF motifs in the FGF insulator (second row, red).
