Fig. 2: Antibiotic activity and in vivo efficacy of selected group A streptogramins.
From: Synthetic group A streptogramin antibiotics that overcome Vat resistance
a, MIC values for selected analogues against an expanded panel of pathogens. Each MIC was obtained in technical triplicate. The bars to the right display in vitro translation that occurs in the presence of 10 μM of each analogue (relative to dimethylsulfoxide (DMSO)). b, MIC values against clinical isolates of S. aureus with Vat resistance genes. Ranges of values obtained from technical replicates are displayed; asterisks indicate MIC values that were obtained in technical triplicate and biological triplicate. c, A mouse thigh model of infection with S. aureus CIP 111304 (n = 5 biologically independent animals per group, with the exception of the 2 h infection control where n = 4 per group, examined over one experiment). Each mouse is individually plotted, the centre line is the mean, and the upper and lower whiskers bound the standard deviation from the mean. For detailed statistical analysis, see Extended Data Table 3. CFU, colony-forming units.
