Extended Data Fig. 3: Effects of iboxamycin on mammalian cells.
From: A synthetic antibiotic class overcoming bacterial multidrug resistance
a, Normalized hemolysis (mean ± s.d.) of human erythrocytes by IBX (n = 3 replicates) and clindamycin (n = 5 replicates) relative to Triton X-100 (n = 45 replicates) measured over one independent experiment. b, c, Mitochondrial ToxGlo data showing effects of IBX on HepG2 cellular membrane integrity and ATP production relative to vehicle-treated control (antimycin serves as a positive control for mitotoxicity). Data are mean ± s.d.; n = 3 technical replicates from one independent experiment. d–f, Comparison of effects of IBX, clindamycin, doxycycline, and azithromycin on cell viability (CellTiter-Blue). Data are the mean ± s.d. of n = 3 independent experiments performed in technical quintuplicate. Where applicable, GI50 values (µM) are reported beside the dose-response curves.
