Extended Data Fig. 2: Comparison of the skin organoid with prenatal and adult skin.

(a) UMAP visualisation of the integrated prenatal skin, adult skin¹⁰ and SkO¹ scRNA-seq datasets, coloured by broad cell types for each dataset. (b) UMAP visualisations of integrated data from prenatal skin and SkO, coloured by epidermal (left) and dermal (right) cell types. (c) Heatmap showing conserved cell states (measured by distance in principal component space) between prenatal skin, adult skin¹⁰ and SkO¹ for broad cell categories. (d) Heatmap showing prediction probabilities (overall and per broad cell category) for a logistic regression model trained on time-encoded prenatal skin and adult skin data (y-axis)¹⁰ and projected onto time-encoded SkO data¹ (x-axis). Colour scale indicates median prediction probabilities. DC, dendritic cells.