Extended Data Fig. 3: Decreased profibrotic signature in fibroblasts with Brd4 deletion in Cx3cr1-expressing monocytes/macrophages.
From: Chromatin remodelling drives immune cell–fibroblast communication in heart failure
A. Expression Feature Plots of cell population markers in nuclei from cardiac tissue. B. Expression of Brd4 in TAC and TAC Brd4-KO across all clusters. C. UMAP plot of fibroblasts coloured by cluster sample identity. D. Expression Feature Plot of Brd4 in fibroblasts. E. UMAP plot of fibroblasts coloured by cluster identity. F. Expression Violin Plots of profibrotic markers across clusters in fibroblasts. G. Expression Feature Plots of profibrotic markers in fibroblasts. H. Sample distribution within fibroblast clusters. I. Heatmap of expression depicting the top 50 genes upregulated in TAC versus TAC Brd4-KO in fibroblasts. J. Heatmap indicating significance (−log10(p−val)) for indicated GO terms in genes upregulated in TAC vs TAC Brd4-KO (left, in red) or upregulated in TAC Brd4-KO vs TAC (right, in blue) in fibroblasts. K. Venn diagram comparing the genes upregulated in fibroblasts in TAC versus TAC + JQ1 (from Fig. 1 analysis) and those upregulated in TAC vs TAC Brd4-KO (from Fig. 2 analysis).
