Extended Data Fig. 4: Changes in fibroblast chromatin accessibility with Brd4 deletion in Cx3cr1-expressing monocytes/macrophages.
From: Chromatin remodelling drives immune cell–fibroblast communication in heart failure
A. Chromatin accessibility gene score of cell population markers across nuclei from cardiac tissue. B. UMAP plot (scATAC-seq) of fibroblasts coloured by cluster identity. C. Chromatin accessibility gene score of Comp, Cilp, Mfap4 and Thbs4 in fibroblasts. D. TF motif enrichment of fibroblast chromatin regions more accessible in TAC versus TAC Brd4-KO. Top 10 motifs are highlighted. A hypergeometric test was used to calculate p-values.
