Extended Data Table 3 List of upregulated genes

From: Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours

  1. Genes which were significantly upregulated (>1.5-fold change and P < 0.05) in trial participants with more than two-fold immune cell influx (IMM) following visugromab monotherapy on treatment (D14) versus pre-treatment (baseline) using two-sided moderated t-test (limma analysis). Log2FC, log2- fold change; P, unadjusted P-values; AveExpr, average expression across all IMM samples (mean log2 intensities).
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