Extended Data Fig. 4: Structure prediction of the triplex structure of β-, γ- or δ-SG using artificial intelligence (AI) programs. | Nature

Extended Data Fig. 4: Structure prediction of the triplex structure of β-, γ- or δ-SG using artificial intelligence (AI) programs.

From: Native DGC structure rationalizes muscular dystrophy-causing mutations

Extended Data Fig. 4: Structure prediction of the triplex structure of β-, γ- or δ-SG using artificial intelligence (AI) programs.

Panels from left to right: cryo-EM model of the β-SG–γ-SG–δ-SG trimer (panel 1) and the predicted models of single-component trimers (panels 2-4). All predicted models were generated using AlphaFold. Regions with pLDDT > 90 are expected to be modelled to high accuracy; regions with pLDDT between 70 and 90 are expected to be modelled well; regions with pLDDT between 50 and 70 are modelled with low confidence and should be treated with caution.

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