Extended Data Fig. 7: Divergent domain orientations between CDHL and SEA in the three CDHL-SEA modules of DGC. | Nature

Extended Data Fig. 7: Divergent domain orientations between CDHL and SEA in the three CDHL-SEA modules of DGC.

From: Native DGC structure rationalizes muscular dystrophy-causing mutations

Extended Data Fig. 7: Divergent domain orientations between CDHL and SEA in the three CDHL-SEA modules of DGC.

a, Structural superposition of the three CDHL-SEA modules within DGC. SEA-CDHL modules are aligned against the SEA domain. b, Unique orientations are essential for the TM-proximal loop of β-DG (left), α-DG (top right) and α-SG (bottom right) to interact with the β-helix. The circle slash denotes interaction disruption by detachment, while the circle cross indicates interaction disruption via atomic clashes.

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