Extended Data Fig. 4: D compartment and local inhibition of DNA replication.
From: Mechanism for local attenuation of DNA replication at double-strand breaks
a, IGV screenshot of the BrdU-seq and γH2AX ChIP-seq sequencing tracks with or without DSB induction via AsiSI activation by 4-Hydroxytamoxifen (4OHT), relative to D compartment. Arrowhead shows one of the AsiSI sites on chromosome 17 (chr17:5,390,222). 2D coordinates of both AsiSI and non-AsiSI D compartments are visible. D compartment coordinates are obtained from14. D comp stands for D compartment. b, Violin plots showing relative log2 fold changes of γH2AX ChIP-seq signal in D compartments with or without AsiSI sites. Shuffle controls are derived from non-D compartment regions of chr1 (p-arm), chr17 and chrX. p-values are calculated using two-sided Wilcoxon rank sum exact test.
