Extended Data Fig. 8: Comparison of hFASN ACP interactions with yeast and bacterial systems.
From: Snapshots of acyl carrier protein shuttling in human fatty acid synthase
a, Alignment of the hFASN ACP with the yeast ACP and bacterial AcpP. b, Structure of the yFASN ACP-DH interaction showing the minor contacts made by Helix III and the DH surface. c, Crystal structure of the bacterial FabA homologue of the DH domain with the ACP crosslinked. The FabA is shown as a surface and AcpP in cartoon form to highlight the extensive interaction made by Helix II at the FabA interface. d, yFASN ACP-ER interaction structure highlighting the broad contacts made by the ACP at the ER interface.
