Extended Data Fig. 1: Generation of Dele1−/− mice.
From: Dual regulation of mitochondrial fusion by Parkin–PINK1 and OMA1
(a) To delete the Dele1 gene in the mouse genome, exon 2 was targeted using the CRISPR-Cas9 editing system with the indicated gRNA. (b) The location of the targeted site in the Dele1 gene is shown. (c) DNA sequencing confirmed that the genome editing removed 10 nucleotides at the position from 45 to 54 and introduced a stop codon after adding four amino acids.
