Extended Data Fig. 12: Expression and correlation with WNT target gene expression and outcomes of R-spondins in human cohorts with MASLD and ALD.
From: Hepatic stellate cells control liver zonation, size and functions via R-spondin 3
a. Expression of RSPO1, RSPO2, RSPO3 and RSPO4 in the GSE49541 MASLD cohort. b-d. Correlation of RSPO1 (b), RSPO2 (c) and RSPO4 (d) mRNA with WNT target genes CYP2E1, CYP1A2 and TBX3 in the GSE135251 MASLD cohort. e-f. Correlation of RSPO1, RSPO2, RSPO3 and RSPO4 mRNA with the expression of WNT target genes TBX3, CYP1A2 and CYP2E1 in the GSE49541 MASLD (e) and the GSE103580 ALD (hASWX) (f) cohorts. g. Expression of RSPO1, RSPO2, RSPO3 and RSPO4 in the GSE103580 ALD cohort. h. Survival and HCC development stratified by RSPO3 expression in the GSE192959 cohort. i. Liver-related coding events by RSPO3 expression in the SteatoSITE MASLD cohort. Box plots represent the interquartile Range (IQR), Q1, median and Q3, each data point represents one individual (a,g). P-values were calculated using Wilcoxon rank-sum test (a,g) and log-rank test (h,i). Correlations were evaluated by pearson correlation coefficient (b-f).
