Extended Data Fig. 4: Pathological examination of patient no. A4-109 from Fig. 2.
From: Oncolytic virus VG161 in refractory hepatocellular carcinoma

a, Pathological results from biopsy samples taken before the patient received VG161. b, A puncture biopsy was performed at the injection site after the VG161 treatment, and the pathological results demonstrated typical tumor cell necrosis. Please note that these biopsies were obtained from a single clinical patient and could not be repeated due to ethical and procedural considerations.